2-Methyl-5-hydroxypyridine → (S)-2-Methyl-5-oxiranylmethoxy-pyridine

HRID 40630

反応式

HRID 40630 の反応式
[CH3:1][C:2]1[N:7]=[CH:6][C:5]([OH:8])=[CH:4][CH:3]=1.[H-].[Na+].[N+](C1C=C(S(O[CH2:24][C@H:25]2[O:27][CH2:26]2)(=O)=O)C=CC=1)([O-])=O>CN(C=O)C>[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([O:8][CH2:24][C@@H:25]2[CH2:26][O:27]2)=[CH:6][N:7]=1

参加物

5

反応物 3

HCID 142752-Methyl-5-hydroxypyridineHCID 24758Sodium hydrideHCID 146490Benzenesulfonic acid, 3-nitro-, (2S)-2-oxiranylmethyl ester

生成物 1

HCID 59686824(S)-2-Methyl-5-oxiranylmethoxy-pyridine

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

6-Methyl-pyridin-3-ol (0.218 g, 2.0 mmol) was placed in a flask with DMF (10 mL) and NaH (60% dispersion in oil, 77 mg, 2.0 mmol) and stirred for 30 min. at room temperature. (S)-glycidyl 3-nitrobenzene sulfonate (0.52 g, 2.0 mmol) was then added to the reaction mixture, which was then stirred at room temperature for 14 hours. The reaction was quenched with NaHCO3 (saturated) and then extracted three times with ethyl acetate. The organic layer was dried with magnesium sulfate, filtered and the solvent was evaporated under reduced pressure to yield crude product which was purified by silica gel chromatography (60% Ethyl acetate/heptane) to yield the title compound as a residue.

後処理

  1. stirringwas then stirred at room temperature for 14 hours
  2. customThe reaction was quenched with NaHCO3 (saturated)
  3. extractionextracted three times with ethyl acetate
  4. dry with materialThe organic layer was dried with magnesium sulfate
  5. filtrationfiltered
  6. customthe solvent was evaporated under reduced pressure
  7. customto yield crude product which
  8. customwas purified by silica gel chromatography (60% Ethyl acetate/heptane)

出典と根拠

ORDレコード
ord-9bf078de8aa64806aabfd30258c40a4a
出典データセット
uspto-grants-2013_09
特許番号
US08530475B2

関連ノート

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