Tetrabutylammonium Fluoride → (3-pyrrolidin-1-ylphenyl)methanol

HRID 406388ノート

反応式

HRID 406388 の反応式
[F-].C([N+](CCCC)(CCCC)CCCC)CCC.[Si]([O:26][CH2:27][C:28]1[CH:29]=[C:30]([N:34]2[CH2:38][CH2:37][CH2:36][CH2:35]2)[CH:31]=[CH:32][CH:33]=1)(C(C)(C)C)(C)C>C1COCC1>[N:34]1([C:30]2[CH:29]=[C:28]([CH2:27][OH:26])[CH:33]=[CH:32][CH:31]=2)[CH2:38][CH2:37][CH2:36][CH2:35]1

参加物

4

反応物 2

HCID 2724141Tetrabutylammonium FluorideHCID 66618917HCID 66618917、化合物

生成物 1

HCID 7162062(3-pyrrolidin-1-ylphenyl)methanol

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

Tetrabutylammonium fluoride (1.0 M solution in THF, 3.8 ml) was added to a solution of 1-[3-(tert-butyldimethylsilyloxymethyl)phenyl]pyrrolidine in THF (20 ml) and the mixture was stirred at room temperature for 3.5 hours. The reaction mixture was concentrated under reduced pressure and the residue was purified by silica gel column chromatography to obtain the title compound (557 mg).

後処理

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. customthe residue was purified by silica gel column chromatography

出典と根拠

ORDレコード
ord-64db9458e0cf4711a293e8a8f1c1930e
出典データセット
uspto-grants-2014_06
特許番号
US08754100B2

反応ノート

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