Methyl iodide → 4-bromo-1,6-dimethylpyridin-2(1H)-one

反応式

[Br:1][C:2]1[CH:7]=[C:6]([CH3:8])[NH:5][C:4](=[O:9])[CH:3]=1.CI.[C:12]([O-])([O-])=O.[K+].[K+]>>[Br:1][C:2]1[CH:7]=[C:6]([CH3:8])[N:5]([CH3:12])[C:4](=[O:9])[CH:3]=1

参加物

反応物 3

HCID 6328Methyl iodide

HCID 11430Potassium Carbonate

HCID 231494724-Bromo-6-methylpyridin-2-ol

生成物 1

HCID 667365044-bromo-1,6-dimethylpyridin-2(1H)-one

実験手順

4-bromo-1,6-dimethylpyridin-2(1H)-one was prepared by methylation of 4-bromo-6-methylpyridin-2(1H)-one with methyl iodide using K2CO3 following a procedure analogous to that described in Example 59 Step 1.

出典と根拠

ORDレコード: ord-a757d77e9ca0428c84033becd6010b12
出典データセット: uspto-grants-2014_06
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08754076B2

反応ノート

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