Benzylamine → N-Benzyl-2,2-dimethoxyethan-1-amine

HRID 406934

反応式

HRID 406934 の反応式
[CH2:1]([NH2:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:9][O:10][CH:11]([O:14][CH3:15])[CH2:12]Cl.[OH-].[Na+]>O>[CH2:1]([NH:8][CH2:12][CH:11]([O:14][CH3:15])[O:10][CH3:9])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

5

反応物 3

HCID 7504BenzylamineHCID 14798Sodium HydroxideHCID 609862-Chloro-1,1-dimethoxyethane

生成物 1

HCID 276572N-Benzyl-2,2-dimethoxyethan-1-amine

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
27.5 °C

実験手順

Benzylamine (0.927 kg), chloroacetaldehydedimethylacetal (0.909 kg), sodium hydroxide solution (0.35 kg) in 2.72 L of water were charged into the flask under stirring at 25-30° C. for 10-15 min. Reaction mass was heated to 100-102° C. under stirring for 30 hrs. After completion of reaction, reaction mass was allowed to settle for 30 min. Two layers are separated and upper product layer was collected, distilled under high vacuum.

後処理

  1. customReaction mass
  2. temperaturewas heated to 100-102° C.
  3. stirringunder stirring for 30 hrs
  4. customAfter completion of reaction, reaction mass
  5. waitto settle for 30 min
  6. customTwo layers are separated
  7. customupper product layer was collected
  8. distillationdistilled under high vacuum

出典と根拠

ORDレコード
ord-90d4d3a682834183b60fa6376a558089
出典データセット
uspto-grants-2014_06
特許番号
US08754215B2

関連ノート

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