Hydrochloric Acid → Hydrochloric Acid

HRID 406992ノート

反応式

HRID 406992 の反応式
C(OC([N:6]1[CH:10]=[C:9]([C:11]2[CH:34]=[CH:33][C:14]3[N:15]([C:18]4[CH:19]=[C:20]([NH:24][C:25]([NH:27][CH2:28][C:29]([F:32])([F:31])[F:30])=[O:26])[CH:21]=[CH:22][CH:23]=4)[CH:16]=[N:17][C:13]=3[CH:12]=2)[CH:8]=[N:7]1)C)C.[ClH:35].O>O1CCCC1>[NH:6]1[CH:10]=[C:9]([C:11]2[CH:34]=[CH:33][C:14]3[N:15]([C:18]4[CH:19]=[C:20]([NH:24][C:25]([NH:27][CH2:28][C:29]([F:32])([F:31])[F:30])=[O:26])[CH:21]=[CH:22][CH:23]=4)[CH:16]=[N:17][C:13]=3[CH:12]=2)[CH:8]=[N:7]1.[ClH:35]

参加物

6

反応物 3

HCID 313Hydrochloric AcidHCID 962WaterHCID 67980487N-(3-{5-[1-(1-ethoxyethyl)-1H-pyrazol-4-yl]-1H-benzimidazol-1-yl]phenyl)-N'-(2,2,2-trifluoroethyl)urea

生成物 2

HCID 313Hydrochloric AcidHCID 67980057N-{3-[5-(1H-pyrazol-4-yl)-1H-benzimidazol-1-yl]phenyl}-N'-(2,2,2-trifluoroethyl)urea

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

The mixture of N-(3-{5-[1-(1-ethoxyethyl)-1H-pyrazol-4-yl]-1H-benzimidazol-1-yl}phenyl)-N′-(2,2,2-trifluoroethyl)urea (190 mg, 0.40 mmol) and 1.0 M hydrogen chloride in water (3 mL, 3 mmol) in tetrahydrofuran (5 mL) was stirred at r.t. 2 hours. The reaction mixture was concentrated under reduced pressure to dryness to afford the desired compound as HCl salt which was directly used in next step reaction without further purification. LCMS (M+H)+: m/z=401.2.

後処理

  1. custom2 hours
  2. concentrationThe reaction mixture was concentrated under reduced pressure to dryness

出典と根拠

ORDレコード
ord-661cda71e74b4fae9c3a179727984545
出典データセット
uspto-grants-2014_06
特許番号
US08754114B2

反応ノート

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