N-Iodosuccinimide → Methyl 3-(3-iodoimidazo[1,2-b]pyridazin-7-yl)benzoate
反応式
[I:1]N1C(=O)CCC1=O.[N:9]1[CH:10]=[CH:11][N:12]2[C:17]=1[CH:16]=[C:15]([C:18]1[CH:19]=[C:20]([CH:25]=[CH:26][CH:27]=1)[C:21]([O:23][CH3:24])=[O:22])[CH:14]=[N:13]2>CN(C=O)C>[I:1][C:11]1[N:12]2[N:13]=[CH:14][C:15]([C:18]3[CH:19]=[C:20]([CH:25]=[CH:26][CH:27]=3)[C:21]([O:23][CH3:24])=[O:22])=[CH:16][C:17]2=[N:9][CH:10]=1参加物
4
実験手順
N-Iodosuccinimide (280 mg, 1.3 mmol) was added to a mixture of methyl 3-imidazo[1,2-b]pyridazin-7-ylbenzoate (160.0 mg, 0.6318 mmol) in DMF (2 mL) and then the reaction was stirred at r.t. for 6 h. The precipitate formed was filtered and washed with ether to provide the desired product (0.12 g). LCMS (M+H)+: m/z=380.0
後処理
- customThe precipitate formed
- filtrationwas filtered
- washwashed with ether
出典と根拠
- ORDレコード
- ord-f21f11b723ee4127a5439a226afdda59
- 出典データセット
- uspto-grants-2014_06
- 特許番号
- US08754114B2
反応ノート
読み込み中…