Acetic Acid → 4-Amino-2-fluorobenzoic acid

HRID 407285

反応式

HRID 407285 の反応式
[F:1][C:2]1[CH:10]=[C:9]([N+:11]([O-])=O)[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].C(O)(=O)C>[Pd].CO>[NH2:11][C:9]1[CH:8]=[CH:7][C:3]([C:4]([OH:6])=[O:5])=[C:2]([F:1])[CH:10]=1

参加物

5

反応物 2

HCID 176Acetic AcidHCID 3026792-Fluoro-4-nitrobenzoic acid

生成物 1

HCID 3026804-Amino-2-fluorobenzoic acid収率 102.7%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

To a solution of 2-fluoro-4-nitrobenzoic acid (1.0 g, 5.4 mmol) in 20 mL of a mixture of acetic acid and methanol (1:1), was added a catalytic amount of palladium on charcoal (25 mg). The reaction was stirred under an atmosphere of hydrogen gas at room temperature overnight. The mixture was then filtered through celite and the solvent was removed by evaporation to yield 0.86 g (100%) of the title compound as a cream coloured solid.

後処理

  1. filtrationThe mixture was then filtered through celite
  2. customthe solvent was removed by evaporation

出典と根拠

ORDレコード
ord-f70d0418ffcb4c2ca79700e34c3bd20b
出典データセット
uspto-grants-2014_06
特許番号
US08754233B2

関連ノート

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