Bromine → 2-Amino-1,3-benzothiazole-7-carboxylic acid

HRID 407291ノート

反応式

HRID 407291 の反応式
[NH:1]([C:5]1[CH:6]=[C:7]([CH:11]=[CH:12][CH:13]=1)[C:8]([OH:10])=[O:9])[C:2]([NH2:4])=[S:3].BrBr>C(Cl)(Cl)Cl>[NH2:4][C:2]1[S:3][C:6]2[C:7]([C:8]([OH:10])=[O:9])=[CH:11][CH:12]=[CH:13][C:5]=2[N:1]=1

参加物

4

反応物 2

HCID 24408BromineHCID 8205751-(3-Carboxyphenyl)-2-thiourea

生成物 1

HCID 202855902-Amino-1,3-benzothiazole-7-carboxylic acid収率 98%

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

To a suspension of 3-thioureidobenzoic acid (1.06 g, 5.41 mmol) in chloroform (25 mL) was added a solution of bromine (0.4 mL, 8.0 mmol) dropwise at room temperature. The resulting mixture was heated under reflux for 3 hrs and allowed to stir at room temperature for 60 hrs. The solvent was evaporated, water was added and the resulting solids were isolated by filtration. The crude product was washed with water and dried to yield 1.03 g (98%) of the title compound as a gray solid.

後処理

  1. temperatureThe resulting mixture was heated
  2. temperatureunder reflux for 3 hrs
  3. customThe solvent was evaporated
  4. additionwater was added
  5. customthe resulting solids were isolated by filtration
  6. washThe crude product was washed with water
  7. customdried

出典と根拠

ORDレコード
ord-7692361a73d9436695e767bb77965cc8
出典データセット
uspto-grants-2014_06
特許番号
US08754233B2

反応ノート

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