Water → Benzenesulfonamide, 4-chloro-N-methyl-3-nitro-
反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([S:8](Cl)(=[O:10])=[O:9])=[CH:4][C:3]=1[N+:12]([O-:14])=[O:13].[CH3:15][NH2:16].O>C1COCC1>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH:16][CH3:15])(=[O:10])=[O:9])=[CH:4][C:3]=1[N+:12]([O-:14])=[O:13]参加物
5
実験手順
To a solution of 4-chloro-3-nitrobenzenesulfonyl chloride (2.0 g, 7.8 mmol) in THF (10 mL) was added excess methylamine (2M solution in THF). The reaction solution was stirred at room temperature for 1 hr. Water was then added and the product was extracted into chloroform. The combined extracts were washed, dried over sodium sulfate, filtered and evaporation to yield 2.3 g of the crude 4-chloro-N-methyl-3-nitrobenzenesulfonamide as an oil. The crude material was used in the subsequent step without further purification.
後処理
- extractionthe product was extracted into chloroform
- washThe combined extracts were washed
- dry with materialdried over sodium sulfate
- filtrationfiltered
- customevaporation
出典と根拠
- ORDレコード
- ord-7e66ffe243c542b88debab339a8b946d
- 出典データセット
- uspto-grants-2014_06
- 特許番号
- US08754233B2
反応ノート
読み込み中…