2-Amino-2-methyl-1-propanol → 4-tert-Butyl-N-(2-hydroxy-1,1-dimethyl-ethyl)-benzamide

HRID 407600

反応式

HRID 407600 の反応式
[C:1]([C:5]1[CH:13]=[CH:12][C:8]([C:9](Cl)=[O:10])=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].[NH2:14][C:15]([CH3:19])([CH3:18])[CH2:16][OH:17]>C(Cl)Cl>[C:1]([C:5]1[CH:13]=[CH:12][C:8]([C:9]([NH:14][C:15]([CH3:19])([CH3:18])[CH2:16][OH:17])=[O:10])=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2]

参加物

4

反応物 2

HCID 118072-Amino-2-methyl-1-propanolHCID 743724-tert-Butylbenzoyl chloride

生成物 1

HCID 3200764-tert-Butyl-N-(2-hydroxy-1,1-dimethyl-ethyl)-benzamide

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

A solution of 101a in DCM (200 mL) was added to a solution of 2-amino-2-methyl-1-propanol (1000 g, 10.5 mol) in CH2Cl2 (2000 mL) dropwise at 0-10° C. A white precipitate formed 5 minutes after the initial addition. The resulting slurry was stirred at room temperature overnight. The solid was removed by filtration and washed with CH2Cl2 (1000 mL). The filtrate was concentrated on by rotary evaporation to give 101b as a light yellow resin which was used in the next step without further purification.

後処理

  1. customA white precipitate formed 5 minutes after the initial
  2. additionaddition
  3. customThe solid was removed by filtration
  4. washwashed with CH2Cl2 (1000 mL)
  5. concentrationThe filtrate was concentrated on by rotary evaporation

出典と根拠

ORDレコード
ord-47edd1bf7e7d42f39019402a8a652c8c
出典データセット
uspto-grants-2014_06
特許番号
US08754077B2

関連ノート

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