Phenol, 2-fluoro-5-methyl- → 4-Bromo-2-fluoro-5-methylphenol

HRID 407981ノート

反応式

HRID 407981 の反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH3:8])=[CH:4][C:3]=1[OH:9].[Br-:10].[Br-].[Br-].C([N+](CCCC)(CCCC)CCCC)CCC.C([N+](CCCC)(CCCC)CCCC)CCC.C([N+](CCCC)(CCCC)CCCC)CCC>C(Cl)(Cl)Cl>[Br:10][C:6]1[C:5]([CH3:8])=[CH:4][C:3]([OH:9])=[C:2]([F:1])[CH:7]=1

参加物

4

反応物 2

HCID 182387Phenol, 2-fluoro-5-methyl-HCID 23500184Tetra-n-butylammonium tribromide

生成物 1

HCID 108997434-Bromo-2-fluoro-5-methylphenol収率 96%

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

2-Fluoro-5-methylphenol (5.0 g, 40 mmol) was dissolved in chloroform (200 mL). Tetrabutylammonium tribromide (19 g, 40 mmol) was added and the reaction stirred at ambient temperature for 30 minutes. The reaction was concentrated and purified over silica gel (20% EtOAc in hexanes) to afford 4-bromo-2-fluoro-5-methylphenol (7.8 g, 38 mmol, 96% yield) as an amber oil.

後処理

  1. concentrationThe reaction was concentrated
  2. custompurified over silica gel (20% EtOAc in hexanes)

出典と根拠

ORDレコード
ord-9bc38907ef0b4dfca8248dd9330b26ec
出典データセット
uspto-grants-2014_06
特許番号
US08754226B2

反応ノート

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