Benzo[d]thiazol-5-ylmethanol → 1,3-Benzothiazole-5-carbaldehyde

HRID 408575ノート

反応式

HRID 408575 の反応式
[S:1]1[C:5]2[CH:6]=[CH:7][C:8]([CH2:10][OH:11])=[CH:9][C:4]=2[N:3]=[CH:2]1>C(Cl)Cl.O=[Mn]=O>[S:1]1[C:5]2[CH:6]=[CH:7][C:8]([CH:10]=[O:11])=[CH:9][C:4]=2[N:3]=[CH:2]1

参加物

4

反応物 1

HCID 22281733Benzo[d]thiazol-5-ylmethanol

生成物 1

HCID 218737181,3-Benzothiazole-5-carbaldehyde

試薬・触媒・溶媒 2

HCID 14801Manganese dioxide触媒HCID 6344Dichloromethane溶媒

反応条件

温度
20 °C

実験手順

To a solution of benzothiazol-5-yl-methanol (1 eq.) in DCM was added MnO2 (10 eq.). The dark suspension was stirred at 20° C. for 15 h, filtered through a pad of celite and the solvent removed under reduced pressure to afford benzothiazole-5-carbaldehyde which was used as such without further purification.

後処理

  1. filtrationfiltered through a pad of celite
  2. customthe solvent removed under reduced pressure

出典と根拠

ORDレコード
ord-369831751b674dc4b9a51dbd8cf70f4a
出典データセット
uspto-grants-2014_06
特許番号
US08759334B2

反応ノート

読み込み中…