Benzyl Bromide → methyl (2R)-1-benzyl-2-methylazetidine-2-carboxylate
反応式
[CH3:1][O:2][C:3]([C@@:5]1([CH3:9])[CH2:8][CH2:7][NH:6]1)=[O:4].[CH2:10](Br)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>C1COCC1>[CH3:1][O:2][C:3]([C@@:5]1([CH3:9])[CH2:8][CH2:7][N:6]1[CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)=[O:4]参加物
4
反応条件
- 温度
- 50 °C
実験手順
To a solution of (R)-2-methyl-azetidine-2-carboxylic acid methyl ester (1 eq.) in THF were added TEA (2 eq.) and benzyl bromide (1 eq.). The reaction was heated at 50° C. for 15 h. The solvent was concentrated under reduced pressure, the crude was purified by chromatography on silica gel (elution with heptane/EtOAc 1/0 to 1/1) to afford (R)-1-benzyl-2-methyl-azetidine-2-carboxylic acid methyl ester.
後処理
- concentrationThe solvent was concentrated under reduced pressure
- customthe crude was purified by chromatography on silica gel (elution with heptane/EtOAc 1/0 to 1/1)
出典と根拠
- ORDレコード
- ord-0cc9d60585034281a0a48241e3e1dfc0
- 出典データセット
- uspto-grants-2014_06
- 特許番号
- US08759334B2
反応ノート
読み込み中…