Methanol → Methyl azetidine-2-carboxylate hydrochloride

HRID 408610ノート

反応式

HRID 408610 の反応式
[NH:1]1[CH2:4][CH2:3][CH:2]1[C:5]([OH:7])=[O:6].S(Cl)([Cl:10])=O.[CH3:12]O>>[ClH:10].[CH3:12][O:6][C:5]([CH:2]1[CH2:3][CH2:4][NH:1]1)=[O:7]

参加物

4

反応物 3

HCID 887MethanolHCID 17288Azetidinecarboxylic AcidHCID 24386Thionyl Chloride

生成物 1

HCID 22476057Methyl azetidine-2-carboxylate hydrochloride

反応条件

温度
20 °C

実験手順

To a solution of azetidine-2-carboxylic acid (1 eq.) in MeOH at 0° C. was added dropwise thionyl chloride (2.5 eq.). The reaction was stirred at 20° C. for 15 h. The crude was concentrated under reduced pressure and used as such without further purification.

後処理

  1. concentrationThe crude was concentrated under reduced pressure
  2. customsuch without further purification

出典と根拠

ORDレコード
ord-7e083845b2e44d96834f03e73cf5b337
出典データセット
uspto-grants-2014_06
特許番号
US08759334B2

反応ノート

読み込み中…