Ammonia → 5-Bromo-4-fluoro-2-nitroaniline

HRID 408736

反応式

HRID 408736 の反応式
[Br:1][C:2]1[CH:7]=[C:6](F)[C:5]([N+:9]([O-:11])=[O:10])=[CH:4][C:3]=1[F:12].[NH3:13]>CO>[Br:1][C:2]1[C:3]([F:12])=[CH:4][C:5]([N+:9]([O-:11])=[O:10])=[C:6]([NH2:13])[CH:7]=1

参加物

4

反応物 2

HCID 222AmmoniaHCID 27362864-Bromo-2,5-difluoronitrobenzene

生成物 1

HCID 669372515-Bromo-4-fluoro-2-nitroaniline

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
60 °C

実験手順

A mixture of 1-bromo-2,5-difluoro-4-nitro-benzene (1.50 g, 6.30 mmol) and 7M ammonia in methanol (25 mL) was heated in a sealed tube at 60° C. for 15 h. The reaction mixture was transferred to a round bottom flask, washing the sealed tube with EtOAc. The reaction mixture was concentrated, and the crude material was used in the next step without further purification.

後処理

  1. customThe reaction mixture was transferred to a round bottom flask
  2. washwashing the sealed tube with EtOAc
  3. concentrationThe reaction mixture was concentrated
  4. customthe crude material was used in the next step without further purification

出典と根拠

ORDレコード
ord-58306cd599c14be59297b4ae57f9a0c7
出典データセット
uspto-grants-2014_06
特許番号
US08759345B2

関連ノート

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