5-Chloro-2-nitro-4-(trifluoromethoxy)aniline → 4-Chloro-5-(trifluoromethoxy)-1,2-benzenediamine
反応式
[Cl:1][C:2]1[C:3]([O:12][C:13]([F:16])([F:15])[F:14])=[CH:4][C:5]([N+:9]([O-])=O)=[C:6]([NH2:8])[CH:7]=1>CN(C=O)C.[Pt]>[Cl:1][C:2]1[CH:7]=[C:6]([NH2:8])[C:5]([NH2:9])=[CH:4][C:3]=1[O:12][C:13]([F:16])([F:14])[F:15]参加物
4
実験手順
5-Chloro-2-nitro-4-trifluoromethoxy-phenylamine (180 g, 0.7 mol, 1.0 equiv.) was dissolved in dry DMF (1 L) and then 5% Pt/C containing 50.2% water (4.0 g) was added. The reaction solution was hydrogenated (50 psi) at room temperature for 16 hours. HPLC analysis indicated complete reaction. MS [M+H]+ found 225.2. The reaction solution was used on the next step without isolation.
後処理
- customat room temperature
- customfor 16 hours
- customreaction
出典と根拠
- ORDレコード
- ord-be5fcd9e6bb34547861cdd15571dab2a
- 出典データセット
- uspto-grants-2014_06
- 特許番号
- US08759345B2
反応ノート
読み込み中…