Sodium borohydride → 1-(5,6-Dichloro-pyridin-3-yl)-ethanol

HRID 408883ノート

反応式

HRID 408883 の反応式
[BH4-].[Na+].[Cl:3][C:4]1[CH:5]=[C:6]([C:11](=[O:13])[CH3:12])[CH:7]=[N:8][C:9]=1[Cl:10]>CO>[Cl:3][C:4]1[CH:5]=[C:6]([CH:11]([OH:13])[CH3:12])[CH:7]=[N:8][C:9]=1[Cl:10]

参加物

4

反応物 2

HCID 4311764Sodium borohydrideHCID 101980061-(5,6-Dichloropyridin-3-yl)ethan-1-one

生成物 1

HCID 115935821-(5,6-Dichloro-pyridin-3-yl)-ethanol

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
0 °C

実験手順

To a well stirred suspension of sodium borohydride (66.21 g, 1.75 mole) in methanol (3.5 L) cooled to 0° C. with a dry ice/acetone bath was added 1-(5,6-dichloro-pyridin-3-yl)-ethanone 8 (665 g, 3.5 mole) at a rate such that the temperature remained at 0° C. After solid addition was complete, the reaction mixture was stirred an additional 1 h, after which time LC/MS analysis of an aliquot showed that the reaction was complete.

後処理

  1. customremained at 0° C
  2. additionAfter solid addition
  3. stirringthe reaction mixture was stirred an additional 1 h

出典と根拠

ORDレコード
ord-e7ebd141092a4354b8776b3756d41520
出典データセット
uspto-grants-2014_06
特許番号
US08759362B2

反応ノート

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