Potassium Hydroxide → Potassium 4-hydroxy-2,2-dimethylbutyrate

HRID 409478

反応式

HRID 409478 の反応式
[CH3:1][C:2]1([CH3:8])[CH2:6][CH2:5][O:4][C:3]1=[O:7].[OH-:9].[K+:10]>C1C=CC2C(C3C=CC(O)=CC=3)(C3C=CC(O)=CC=3)OC(=O)C=2C=1.CCO.O>[OH:4][CH2:5][CH2:6][C:2]([CH3:8])([CH3:1])[C:3]([O-:9])=[O:7].[K+:10]

参加物

5

反応物 2

HCID 14797Potassium HydroxideHCID 947462,2-Dimethyl-4-butyrolactone

生成物 1

HCID 23712640Potassium 4-hydroxy-2,2-dimethylbutyrate収率 71.1%

試薬・触媒・溶媒 2

HCID 4764Phenolphthalein触媒HCID 19096565Water ethanol溶媒

反応条件

温度
105 °C

実験手順

A mixture of dihydro-3,3-dimethyl-2(3H)-furanone (10 mmol; 1.14 g), aqueous 1 M KOH solution (10 mmol) and one drop of phenolphthalein indicator (0.5% w/v in EtOH/water (1:1)) is stirred at 105° C. for 3.5 hours. The mixture is cooled to ambient temperature and concentration under reduced pressure. To the residue is added 10 mL of EtOH. To the solution is added 50 ml of Et2O, and the solid isolated by filtration and dried under 100 mbar at 50° C. to give potassium 4-hydroxy-2,2-dimethylbutyrate (1.21 g, 71%).

後処理

  1. temperatureThe mixture is cooled to ambient temperature
  2. concentrationconcentration under reduced pressure
  3. additionTo the residue is added 10 mL of EtOH
  4. additionTo the solution is added 50 ml of Et2O
  5. customthe solid isolated by filtration
  6. customdried under 100 mbar at 50° C.

出典と根拠

ORDレコード
ord-35ae9b314b1645268a359b196c797298
出典データセット
uspto-grants-2014_06
特許番号
US08759365B2

関連ノート

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