Isophthaloyl chloride → 1,3-Benzenedimethanol

To a two-liter, 3-necked round-bottomed flask equipped with a 500-ml constant pressure addition funnel, an overhead stirrer, a thermocouple and a nitrogen inlet was added 27 g (0.74 mol) of lithium aluminum hydride (95%) and 1000 ml of anhydrous tetrahydrofuran (THF). The addition funnel was charged with a solution of 100 g (0.493 mol) of isophthaloyl dichloride in 400 ml of anhydrous THF. Diacylchloride was added slowly over a period of 2 hours with cooling in an ice bath. Once addition was complete the ice bath was removed and the suspension allowed to reach room temperature for four hours at which time it was re-cooled and 200 ml of ethyl acetate was slowly added to decompose the remaining hydride. The addition funnel was recharged with 200 ml of 2M NaOH, which was then added slowly with vigorous stirring until the ensuing suspension became granular in appearance. The suspension was filtered and well washed with ethyl acetate. The combined filtrate and washings were then washed with brine, dried over anhydrous magnesium sulfate and evaporated on a rotary evaporator to yield 64 g (94%) of the title compound as a clear, colorless oil which solidified upon standing.

1. customTo a two-liter, 3-necked round-bottomed flask equipped with a 500-ml constant pressure addition funnel, an overhead stirrer
2. temperaturewith cooling in an ice bath
3. additionOnce addition
4. customwas removed
5. temperaturewas re-cooled
6. addition200 ml of ethyl acetate was slowly added
7. additionwas then added slowly
8. filtrationThe suspension was filtered
9. washwell washed with ethyl acetate
10. washThe combined filtrate and washings were then washed with brine
11. dry with materialdried over anhydrous magnesium sulfate
12. customevaporated on a rotary evaporator

ORDレコード

ord-d7851eaebc9e40c982cac36db86eebfe

出典データセット

uspto-grants-2014_06

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US08759415B2