Hydrochloric Acid → 4-(2-Hydroxyethyl)cyclohexan-1-one
反応式
[O:1]1[C:5]2([CH2:10][CH2:9][CH:8]([CH2:11][CH2:12][OH:13])[CH2:7][CH2:6]2)OCC1.C1COCC1.Cl.C([O-])(O)=O.[Na+]>CC(C)=O>[OH:13][CH2:12][CH2:11][CH:8]1[CH2:9][CH2:10][C:5](=[O:1])[CH2:6][CH2:7]1参加物
6
反応条件
- 温度
- 25 °C
実験手順
2-(1,4-Dioxaspiro[4.5]dec-8-yl)ethanol (2.70 g, 0.0145 mol) was dissolved in acetone (10.00 mL) and THF (10.00 mL) and 6.00 M HCl (6.00 mL) was added. The reaction was stirred at 25° C. for 16 hours, neutralized with NaHCO3 solution and was then extracted with ethyl acetate. The organic extracts were washed with water, and with saturated NaCl, then dried (MgSO4) and concentrated in vacuo. The crude product was used in the next reaction without further purification. 1H NMR (CDCl3): 3.75 (m, 2H), 2.36 (m, 4H), 1.20-2.13 (m, 7H).
後処理
- extractionwas then extracted with ethyl acetate
- washThe organic extracts were washed with water
- dry with materialwith saturated NaCl, then dried (MgSO4)
- concentrationconcentrated in vacuo
- customThe crude product was used in the next reaction without further purification
出典と根拠
- ORDレコード
- ord-febdcda125884427ad891da3ebe58e0e
- 出典データセット
- uspto-grants-2013_09
- 特許番号
- US08530485B2
反応ノート
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