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Methyl indole-6-carboxylate → methyl 3-fluoro-1H-indole-6-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl indole-6-carboxylate | HCID 639844 | — |
| 反応物 | 1-Fluoro-2,4,6-trimethylpyridinium Trifluoromethanesulfonate [Fluorinating Reagent] | HCID 2724575 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | methyl 3-fluoro-1H-indole-6-carboxylate | HCID 59625843 | — |
反応手順
A solution of methyl 1H-indole-6-carboxylate 20a (11.4 mmol, 2.0 g) and N-fluoro-2,4,6-trimethylpyridinium triflate (14.8 mmol, 4.3 g) in MeOH (100 mL) was heated at reflux for 18 h. The reaction mixture was concentrated and purified by flash column chromatography (silica gel, 15-20% EtOAc/hexanes) to give compound 20b as an off-white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08759533B2 |
| 出典データセット | uspto-grants-2014_06 |
| ORD ID | ord-73b9c93dbb2d4175912811e925bef103 |
| 出典メモ | uspto-grants-2014_06 |