Dimethylformamide → Methyl 2-chloro-1,3-benzoxazole-6-carboxylate
反応式
S[C:2]1[O:3][C:4]2[CH:10]=[C:9]([C:11]([O:13][CH3:14])=[O:12])[CH:8]=[CH:7][C:5]=2[N:6]=1.O=S(Cl)[Cl:17].CN(C=O)C>>[Cl:17][C:2]1[O:3][C:4]2[CH:10]=[C:9]([C:11]([O:13][CH3:14])=[O:12])[CH:8]=[CH:7][C:5]=2[N:6]=1参加物
4
実験手順
To Compound 4 (2 g, 9.5 mmol), SOCl2 (9.8 ml, 134 mmol) and DMF (0.8 mL, 10 mmol) was added at room temperature. The reaction mixture heated to reflux for 15 min. The solvent was removed under reduced pressure. The crude oil was azeotroped with xylene twice.
後処理
- temperatureThe reaction mixture heated
- temperatureto reflux for 15 min
- customThe solvent was removed under reduced pressure
- customThe crude oil was azeotroped with xylene twice
出典と根拠
- ORDレコード
- ord-c894aa49e5ff4011a3709e8e3952a4d1
- 出典データセット
- uspto-grants-2014_06
- 特許番号
- US08759539B2
反応ノート
読み込み中…