Hydrochloric Acid → (E)-3-Cyclopentylacrylic acid
反応式
[C:1](O)(=O)[CH2:2][C:3]([OH:5])=[O:4].N1[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]1.C1(C=O)CCCC1.Cl>N1C=CC=CC=1>[CH:9]1(/[CH:1]=[CH:2]/[C:3]([OH:5])=[O:4])[CH2:13][CH2:12][CH2:11][CH2:10]1参加物
6
反応条件
- 温度
- 40 °C
実験手順
To a solution of malonic acid (1.06 g, 10.2 mol) in pyridine (1.25 mL) was added piperidine (0.15 mL) and cyclopentanecarbaldehyde (1.00 g, 10.2 mmol). The mixture was heated to 40° C. for 2 hours, followed by stirring at room temperature for 16 hours. The mixture was then cooled in an ice bath and 2N HCl was added to acidify. The product was extracted with ether. The ether extract was washed with aq. HCl and brine, dried over sodium sulfate, filtered, and the solvent was removed in vacuo to afford the product (1.30 g, 77%), which was used without further purification.
後処理
- temperatureThe mixture was then cooled in an ice bath
- extractionThe product was extracted with ether
- extractionThe ether extract
- washwas washed with aq. HCl and brine
- dry with materialdried over sodium sulfate
- filtrationfiltered
- customthe solvent was removed in vacuo
出典と根拠
- ORDレコード
- ord-7514952082aa4690a649a793d88fb62a
- 出典データセット
- uspto-grants-2013_09
- 特許番号
- US08530485B2
反応ノート
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