Hydrochloric Acid → 2-(4-(Methoxycarbonyl)-2-methylphenyl)acetic acid

HRID 410041ノート

反応式

HRID 410041 の反応式
C([O:3][C:4](=[O:17])[CH2:5][C:6]1[CH:15]=[CH:14][C:9]([C:10]([O:12][CH3:13])=[O:11])=[CH:8][C:7]=1[CH3:16])C.O.[Li+].[OH-].Cl>CO>[CH3:13][O:12][C:10]([C:9]1[CH:14]=[CH:15][C:6]([CH2:5][C:4]([OH:17])=[O:3])=[C:7]([CH3:16])[CH:8]=1)=[O:11]

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 3939Lithium HydroxideHCID 67365879Methyl 4-(2-ethoxy-2-oxoethyl)-3-methylbenzoate

生成物 1

HCID 575552242-(4-(Methoxycarbonyl)-2-methylphenyl)acetic acid収率 91.5%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

Methyl 4-(2-ethoxy-2-oxoethyl)-3-methylbenzoate (366 mg) was suspended in MeOH (10 ml) and H2O (2 ml) and treated with LiOH (48 mg) over 3 days. After the reaction mixture was acidified with 1N HCl, the product was extracted with EtOAc. Evaporation and drying in vacuum afforded the desired product (295 mg).

後処理

  1. extractionthe product was extracted with EtOAc
  2. customEvaporation
  3. customdrying in vacuum

出典と根拠

ORDレコード
ord-a479f492c6764007a2bacc19846ab445
出典データセット
uspto-grants-2014_06
特許番号
US08759548B2

反応ノート

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