Hydrochloric Acid → Hydrochloric Acid
反応式
[N+:1]([C:4]1[C:5]([F:13])=[C:6]([CH:9]=[CH:10][C:11]=1[F:12])[C:7]#[N:8])([O-])=O.[ClH:14]>[Pd].CO>[NH2:8][CH2:7][C:6]1[C:5]([F:13])=[C:4]([C:11]([F:12])=[CH:10][CH:9]=1)[NH2:1].[ClH:14]参加物
6
実験手順
A mixture of 3-nitro-2,4-difluoro-benzonitrile (500 mg, 2.72 mmol), Pd/C (200 mg), conc. HCl (1.50 mL, 18.0 mmol) and MeOH (25 mL) is stirred at rt overnight under a hydrogen atmosphere (3.2 bar). The catalyst is removed by filtration, the filtrate is concentrated and evaporated twice from EtOH to give the sub-title compound as HCl salt.
後処理
- customThe catalyst is removed by filtration
- concentrationthe filtrate is concentrated
- customevaporated twice from EtOH
出典と根拠
- ORDレコード
- ord-69ea13403f5d4ec7af2c1644d956d23f
- 出典データセット
- uspto-grants-2014_06
- 特許番号
- US08759537B2
反応ノート
読み込み中…