Ammonia → Ethyl 4-amino-2-fluoro-5-nitrobenzoate
反応式
[F:1][C:2]1[CH:12]=[C:11](F)[C:10]([N+:14]([O-:16])=[O:15])=[CH:9][C:3]=1[C:4]([O:6][CH2:7][CH3:8])=[O:5].[NH3:17]>C1COCC1>[F:1][C:2]1[CH:12]=[C:11]([NH2:17])[C:10]([N+:14]([O-:16])=[O:15])=[CH:9][C:3]=1[C:4]([O:6][CH2:7][CH3:8])=[O:5]参加物
4
実験手順
A mixture of ethyl 2,4-difluoro-5-nitro-benzoate (5.0 g, 21 mmol), 5.2 mL conc. NH3 and THF (25 mL) is stirred for 30 min in an ice bath and overnight at rt. The mixture is concentrated and diluted with water. The precipitate is filtered, washed with water and dried at 55° C. to furnish the crude sub-title compound.
後処理
- concentrationThe mixture is concentrated
- additiondiluted with water
- filtrationThe precipitate is filtered
- washwashed with water
- customdried at 55° C.
出典と根拠
- ORDレコード
- ord-5adf13836dd14585ac25c36bd8c0db63
- 出典データセット
- uspto-grants-2014_06
- 特許番号
- US08759537B2
反応ノート
読み込み中…