Methylamine → N-methyl-3-(methylamino)-4-nitrobenzamide

HRID 410758ノート

反応式

HRID 410758 の反応式
[CH3:1][NH:2][C:3]1[CH:4]=[C:5]([CH:9]=[CH:10][C:11]=1[N+:12]([O-:14])=[O:13])[C:6]([OH:8])=O.C[CH2:16][N:17](C(C)C)C(C)C.CN>C1C=CC(P(N=[N+]=[N-])(C2C=CC=CC=2)=O)=CC=1>[CH3:16][NH:17][C:6](=[O:8])[C:5]1[CH:9]=[CH:10][C:11]([N+:12]([O-:14])=[O:13])=[C:3]([NH:2][CH3:1])[CH:4]=1

参加物

5

反応物 3

HCID 6329MethylamineHCID 81531DiisopropylethylamineHCID 221846233-(Methylamino)-4-nitrobenzoic acid

生成物 1

HCID 60144426N-methyl-3-(methylamino)-4-nitrobenzamide

試薬・触媒・溶媒 1

HCID 199401P,P-Diphenylphosphinic azide溶媒

実験手順

N-Methyl-3-methylamino-4-nitro-benzamide (407 mg) was prepared by following General Procedure N starting from 3-methylamino-4-nitro-benzoic acid (500 mg), DPPA (550 uL), DIEA (445 uL), and methylamine (2 M in THF, 2.55 mL).

出典と根拠

ORDレコード
ord-7d2304e356624088a78609476118870f
出典データセット
uspto-grants-2014_06
特許番号
US08759535B2

反応ノート

読み込み中…