2-Diethylamino-4-methylamino-5-nitro-benzoic acid methyl ester → 5-Amino-2-diethylamino-4-methylamino-benzoic acid methyl ester

HRID 410793ノート

反応式

HRID 410793 の反応式
[CH3:1][O:2][C:3](=[O:20])[C:4]1[CH:9]=[C:8]([N+:10]([O-])=O)[C:7]([NH:13][CH3:14])=[CH:6][C:5]=1[N:15]([CH2:18][CH3:19])[CH2:16][CH3:17]>[Pd]>[CH3:1][O:2][C:3](=[O:20])[C:4]1[CH:9]=[C:8]([NH2:10])[C:7]([NH:13][CH3:14])=[CH:6][C:5]=1[N:15]([CH2:16][CH3:17])[CH2:18][CH3:19]

参加物

3

反応物 1

HCID 673332942-Diethylamino-4-methylamino-5-nitro-benzoic acid methyl ester

生成物 1

HCID 673331485-Amino-2-diethylamino-4-methylamino-benzoic acid methyl ester収率 94.7%

試薬・触媒・溶媒 1

HCID 23938Palladium触媒

実験手順

5-Amino-2-diethylamino-4-methylamino-benzoic acid methyl ester (1.015 g) was prepared by following General Procedure B starting from 2-diethylamino-4-methylamino-5-nitro-benzoic acid methyl ester (1.2 g) and Pd/C (10% by weight, 120 mg). The crude product was used in the next step without further purification.

後処理

  1. customThe crude product was used in the next step without further purification

出典と根拠

ORDレコード
ord-81cb3ae7de1243119d98e156d43280b1
出典データセット
uspto-grants-2014_06
特許番号
US08759535B2

反応ノート

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