Methylamine → Methyl 4-(methylamino)-3-nitrobenzoate

HRID 410825

反応式

HRID 410825 の反応式
Cl[C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[CH:4][C:3]=1[N+:12]([O-:14])=[O:13].[CH3:15][NH2:16]>CN(C=O)C>[CH3:9][O:8][C:6](=[O:7])[C:5]1[CH:10]=[CH:11][C:2]([NH:16][CH3:15])=[C:3]([N+:12]([O-:14])=[O:13])[CH:4]=1

参加物

4

反応物 2

HCID 6329MethylamineHCID 735797Methyl 4-chloro-3-nitrobenzoate

生成物 1

HCID 7650848Methyl 4-(methylamino)-3-nitrobenzoate

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

4-Methylamino-3-nitro-benzoic acid methyl ester (822 mg) was prepared by following General Procedure A starting from methyl 4-chloro-3-nitrobenzoate (1.0 g) and methylamine (2 M in THF, 6.95 mL) in DMF. The crude product was used in the next step without further purification.

後処理

  1. customThe crude product was used in the next step without further purification

出典と根拠

ORDレコード
ord-4c0699298eac44c896b94e49de542ae4
出典データセット
uspto-grants-2014_06
特許番号
US08759535B2

関連ノート

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