化工社化工社 化学情報印刷レポート · 研究参考用
1,1'-Thiocarbonyldiimidazole → 2-(6-Methanesulfonyl-benzothiazol-2-ylamino)-1-methyl-1H-benzoimidazole-5-carboxylic acid methyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1,1'-Thiocarbonyldiimidazole | HCID 80264 | — |
| 反応物 | 2-Benzothiazolamine, 6-(methylsulfonyl)- | HCID 87152 | — |
| 反応物 | Methyl 3-amino-4-(methylamino)benzoate | HCID 15586064 | — |
| 溶媒 | 1,2-Dichloroethane | HCID 11 | — |
| 生成物 | 2-(6-Methanesulfonyl-benzothiazol-2-ylamino)-1-methyl-1H-benzoimidazole-5-carboxylic acid methyl ester | HCID 58397583 | 78.9% |
反応手順
2-(6-Methanesulfonyl-benzothiazol-2-ylamino)-1-methyl-1H-benzoimidazole-5-carboxylic acid methyl ester (1.64 g) was prepared by following General Procedure D starting from 3-amino-4-methylamino-benzoic acid methyl ester (0.9 g), 2-amino-6-methanesulfonyl-benzothiazole (1.14 g), 1,1′-thiocarbonyldiimidazole (1.07 g), and EDC (1.15 g). LC/MS: m/z 418.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08759535B2 |
| 出典データセット | uspto-grants-2014_06 |
| ORD ID | ord-ce39c1b176cc4314aaf33a9cce5cd659 |
| 出典メモ | uspto-grants-2014_06 |