2-Methoxyethylamine → Methyl 4-((2-methoxyethyl)amino)-3-nitrobenzoate

HRID 410902ノート

反応式

HRID 410902 の反応式
Cl[C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[CH:4][C:3]=1[N+:12]([O-:14])=[O:13].[CH3:15][O:16][CH2:17][CH2:18][NH2:19]>CN(C=O)C>[CH3:9][O:8][C:6](=[O:7])[C:5]1[CH:10]=[CH:11][C:2]([NH:19][CH2:18][CH2:17][O:16][CH3:15])=[C:3]([N+:12]([O-:14])=[O:13])[CH:4]=1

参加物

4

反応物 2

HCID 80182-MethoxyethylamineHCID 735797Methyl 4-chloro-3-nitrobenzoate

生成物 1

HCID 67335214Methyl 4-((2-methoxyethyl)amino)-3-nitrobenzoate収率 81.4%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

4-(2-Methoxy-ethylamino)-3-nitro-benzoic acid methyl ester (960.0 mg) was prepared by following General Procedure A starting from methyl 4-chloro-3-nitrobenzoate (1.0 g) and 2-methoxy-ethylamine (413.0 mg) in DMF (10.0 mL). The crude product was used in the next step without further purification.

後処理

  1. customThe crude product was used in the next step without further purification

出典と根拠

ORDレコード
ord-2d6bd3c84a2c4c2eb409de875b20f45e
出典データセット
uspto-grants-2014_06
特許番号
US08759535B2

反応ノート

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