Methyl 4-((2-methoxyethyl)amino)-3-nitrobenzoate → Methyl 3-amino-4-[(2-methoxyethyl)amino]benzoate

HRID 410903ノート

反応式

HRID 410903 の反応式
[CH3:1][O:2][C:3](=[O:18])[C:4]1[CH:9]=[CH:8][C:7]([NH:10][CH2:11][CH2:12][O:13][CH3:14])=[C:6]([N+:15]([O-])=O)[CH:5]=1>CO.CCOC(C)=O.[Pd]>[CH3:1][O:2][C:3](=[O:18])[C:4]1[CH:9]=[CH:8][C:7]([NH:10][CH2:11][CH2:12][O:13][CH3:14])=[C:6]([NH2:15])[CH:5]=1

参加物

4

反応物 1

HCID 67335214Methyl 4-((2-methoxyethyl)amino)-3-nitrobenzoate

生成物 1

HCID 50742440Methyl 3-amino-4-[(2-methoxyethyl)amino]benzoate収率 94.5%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 21584119Ethylacetate methanol溶媒

実験手順

3-Amino-4-(2-methoxy-ethylamino)-benzoic acid methyl ester (800.0 mg) was prepared by following General Procedure B starting from 4-(2-methoxy-ethylamino)-3-nitro-benzoic acid methyl ester (960.0 mg) and Pd/C (20% by weight, 190.0 mg) in MeOH:EtOAc (1:1, 10.0 mL). The crude product was used in the next step without further purification.

後処理

  1. customThe crude product was used in the next step without further purification

出典と根拠

ORDレコード
ord-9041e3f6b2594ed994089263f2040a94
出典データセット
uspto-grants-2014_06
特許番号
US08759535B2

反応ノート

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