Ethylamine hydrochloride → Methyl 4-(ethylamino)-3-nitrobenzoate
反応式
Cl[C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[CH:4][C:3]=1[N+:12]([O-:14])=[O:13].[CH3:15][CH2:16][N:17](C(C)C)C(C)C.Cl.C(N)C>CN(C=O)C>[CH3:9][O:8][C:6](=[O:7])[C:5]1[CH:10]=[CH:11][C:2]([NH:17][CH2:16][CH3:15])=[C:3]([N+:12]([O-:14])=[O:13])[CH:4]=1参加物
5
実験手順
4-Ethylamino-3-nitro-benzoic acid methyl ester (8.3 g) was prepared by following General Procedure A starting from methyl 4-chloro-3-nitrobenzoate (10.0 g), DIEA (1.6 mL) and ethylamine hydrochloride salt (4.5 g) in DMF (50.0 mL). The crude product was used in the next step without further purification.
後処理
- customThe crude product was used in the next step without further purification
出典と根拠
- ORDレコード
- ord-50fa9306b5db42fbb3074b43b35594d7
- 出典データセット
- uspto-grants-2014_06
- 特許番号
- US08759535B2
反応ノート
読み込み中…