(4-Methylamino-3-nitro-benzoylamino)-acetic acid tert-butyl ester → (4-Methylamino-3-nitro-benzoylamino)-acetic acid

HRID 411051

反応式

HRID 411051 の反応式
C([O:5][C:6](=[O:22])[CH2:7][NH:8][C:9](=[O:21])[C:10]1[CH:15]=[CH:14][C:13]([NH:16][CH3:17])=[C:12]([N+:18]([O-:20])=[O:19])[CH:11]=1)(C)(C)C>Cl.O1CCOCC1.C(Cl)Cl>[CH3:17][NH:16][C:13]1[CH:14]=[CH:15][C:10]([C:9]([NH:8][CH2:7][C:6]([OH:22])=[O:5])=[O:21])=[CH:11][C:12]=1[N+:18]([O-:20])=[O:19]

参加物

4

反応物 1

HCID 67332520(4-Methylamino-3-nitro-benzoylamino)-acetic acid tert-butyl ester

生成物 1

HCID 67334647(4-Methylamino-3-nitro-benzoylamino)-acetic acid収率 81.4%

試薬・触媒・溶媒 2

HCID 6344Dichloromethane溶媒HCID 204431481,4-Dioxane hydrochloride溶媒

実験手順

(4-Methylamino-3-nitro-benzoylamino)-acetic acid (800 mg) was prepared starting from (4-methylamino-3-nitro-benzoylamino)-acetic acid tert-butyl ester (1.2 g) in 4 M HCl-dioxane (2 mL) and DCM (2 mL). The reaction was stirred at room temperature for 8 h. The solvent was evaporated to isolate pure compound without any further purification.

後処理

  1. customThe solvent was evaporated
  2. customto isolate pure compound
  3. customwithout any further purification

出典と根拠

ORDレコード
ord-040cee8d28ca45deb8dd242cb4abb8bb
出典データセット
uspto-grants-2014_06
特許番号
US08759535B2

関連ノート

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