Lithium Hydroxide → (R)-2-{[2-(6-Chloro-benzothiazol-2-ylamino)-1-methyl-1H-benzoimidazole-5-carbonyl]-amino}-propionic acid

HRID 411091

反応式

HRID 411091 の反応式
C[O:2][C:3](=[O:30])[C@H:4]([NH:6][C:7]([C:9]1[CH:29]=[CH:28][C:12]2[N:13]([CH3:27])[C:14]([NH:16][C:17]3[S:18][C:19]4[CH:25]=[C:24]([Cl:26])[CH:23]=[CH:22][C:20]=4[N:21]=3)=[N:15][C:11]=2[CH:10]=1)=[O:8])[CH3:5].[OH-].[Li+]>>[Cl:26][C:24]1[CH:23]=[CH:22][C:20]2[N:21]=[C:17]([NH:16][C:14]3[N:13]([CH3:27])[C:12]4[CH:28]=[CH:29][C:9]([C:7]([NH:6][C@H:4]([CH3:5])[C:3]([OH:30])=[O:2])=[O:8])=[CH:10][C:11]=4[N:15]=3)[S:18][C:19]=2[CH:25]=1

参加物

3

反応物 2

HCID 3939Lithium HydroxideHCID 86657002(R)-2-{[2-(6-Chloro-benzothiazol-2-ylamino)-1-methyl-1H-benzoimidazole-5-carbonyl]-amino}-propionic acid methyl ester

生成物 1

HCID 86657003(R)-2-{[2-(6-Chloro-benzothiazol-2-ylamino)-1-methyl-1H-benzoimidazole-5-carbonyl]-amino}-propionic acid収率 74.1%

実験手順

(R)-2-{[2-(6-Chloro-benzothiazol-2-ylamino)-1-methyl-1H-benzoimidazole-5-carbonyl]-amino}-propionic acid (341 mg) was prepared by following General Procedure E starting from (R)-2-{[2-(6-chloro-benzothiazol-2-ylamino)-1-methyl-1H-benzoimidazole-5-carbonyl]-amino}-propionic acid methyl ester (475 mg) and lithium hydroxide (180 mg).

出典と根拠

ORDレコード
ord-ca4bebfafb604c78b917b967c23df269
出典データセット
uspto-grants-2014_06
特許番号
US08759535B2

関連ノート

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