Sodium Iodide → 2-Iodo-N-[3,4-bis(phenylmethoxy)phenyl]acetamide

HRID 4113

反応式

HRID 4113 の反応式
Cl[CH2:2][C:3]([NH:5][C:6]1[CH:11]=[CH:10][C:9]([O:12][CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[C:8]([O:20][CH2:21][C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[CH:7]=1)=[O:4].[I-:28].[Na+]>CC(C)=O>[I:28][CH2:2][C:3]([NH:5][C:6]1[CH:11]=[CH:10][C:9]([O:12][CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[C:8]([O:20][CH2:21][C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[CH:7]=1)=[O:4]

参加物

4

反応物 2

HCID 5238Sodium IodideHCID 201534662-Chloro-N-[3,4-bis(phenylmethoxy)phenyl]acetamide

生成物 1

HCID 201534732-Iodo-N-[3,4-bis(phenylmethoxy)phenyl]acetamide収率 60.4%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

A solution of 2-chloro-N-[3,4-bis(phenylmethoxy)phenyl]acetamide (8.98 g, 23.5 mmol) and sodium iodide (3.53 g, 23.5 mmol) in acetone (75 ml) was refluxed for two hours and allowed to stand overnight at room temperature. The reaction was filtered hot to remove the sodium iodide and a precipitate formed in the cold filtrate which was collected and washed with cold acetone to give, upon drying, 6.71 g (14.2 mmol) of the title compound. A second crop was obtained from cold acetone (1.0 g).

後処理

  1. filtrationThe reaction was filtered hot
  2. customto remove the sodium iodide
  3. customa precipitate formed in the cold filtrate which
  4. customwas collected
  5. washwashed with cold acetone
  6. customto give
  7. customupon drying

出典と根拠

ORDレコード
ord-b6175eeac55148129b4ba8d24ceb3f10
出典データセット
uspto-grants-1988_02
特許番号
US04723002

関連ノート

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