3,4-Dichloroaniline → N-(3,4-dichlorophenyl)alanine n-propyl Ester

HRID 411424

反応式

HRID 411424 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH:6]=[CH:7][C:8]=1[Cl:9])[NH2:5].[C:10]([O:15][CH2:16][CH2:17][CH3:18])(=[O:14])[C:11]([CH3:13])=O>>[CH2:16]([O:15][C:10](=[O:14])[C@H:11]([CH3:13])[NH:5][C:4]1[CH:6]=[CH:7][C:8]([Cl:9])=[C:2]([Cl:1])[CH:3]=1)[CH2:17][CH3:18]

参加物

3

反応物 2

HCID 72573,4-DichloroanilineHCID 523918Propyl pyruvate

生成物 1

HCID 53940447N-(3,4-dichlorophenyl)alanine n-propyl Ester

実験手順

Following General Procedure AA above and using 3,4-dichloroaniline (Aldrich) and n-propyl pyruvate (prepared by following General Procedure AO above using n-propanol in place of iso-butanol), the title compound was prepared as an oil. The reaction was monitered by tlc on silica gel (Rf=0.5 in 25% EtOAc/hexanes) and purification was by preparative plate chromatography (silica gel using 25% EtOAc/hexanes as the eluant).

後処理

  1. customThe reaction was monitered by tlc on silica gel (Rf=0.5 in 25% EtOAc/hexanes) and purification

出典と根拠

ORDレコード
ord-a2caa3af161f4da1b9ee41536f330076
出典データセット
uspto-grants-2003_05
特許番号
US06559141B2

関連ノート

読み込み中…