1,2-Dibromoethane → 4-(2-Bromoethoxy)benzonitrile
反応式
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([OH:9])=[CH:5][CH:4]=1)#[N:2].C([O-])([O-])=O.[K+].[K+].[Br:16][CH2:17][CH2:18]Br>CC#N>[Br:16][CH2:17][CH2:18][O:9][C:6]1[CH:7]=[CH:8][C:3]([C:1]#[N:2])=[CH:4][CH:5]=1参加物
5
実験手順
A mixture of 4-cyanophenol (35.7 g, 0.3 mol), K2CO3 (41.4 g, 0.3 mol) and 1,2-dibromoethane (561 g, 3.0 mol) in MeCN (450 mL) was stirred under reflux overnight. The mixture was filtered and evaporated to give 30.2 g (45%) of the sub-title compound, which was used without further purification.
後処理
- temperatureunder reflux overnight
- filtrationThe mixture was filtered
- customevaporated
出典と根拠
- ORDレコード
- ord-c1e2e1e3d0114e84aa5e6d1e459a8b16
- 出典データセット
- uspto-grants-2003_05
- 特許番号
- US06559162B2
反応ノート
読み込み中…