Water → 2-(4-Acetyl-1-piperazinyl)ethyl 1H-imidazole-1-carboxylate

HRID 411555

反応式

HRID 411555 の反応式
[C:1](N1C=CN=C1)([N:3]1[CH:7]=[CH:6][N:5]=[CH:4]1)=[O:2].[OH:13][CH2:14][CH2:15][N:16]1[CH2:21][CH2:20][N:19]([C:22](=[O:24])[CH3:23])[CH2:18][CH2:17]1.O>C(Cl)Cl>[N:3]1([C:1]([O:13][CH2:14][CH2:15][N:16]2[CH2:21][CH2:20][N:19]([C:22](=[O:24])[CH3:23])[CH2:18][CH2:17]2)=[O:2])[CH:7]=[CH:6][N:5]=[CH:4]1

参加物

5

反応物 3

HCID 962WaterHCID 682631,1'-CarbonyldiimidazoleHCID 47396291-Acetyl-4-(2-hydroxyethyl)piperazine

生成物 1

HCID 218676622-(4-Acetyl-1-piperazinyl)ethyl 1H-imidazole-1-carboxylate収率 96%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

A solution of 1,1′-carbonyldiimidazole (5 g, 31 mmol) in DCM (200 mL) was treated with a solution of 1-[4-(2-hydroxyethyl)-1-piperazinyl]-1-ethanone (see step (i) above; 5 g, 29 mmol) in DCM (50 mL). The reaction mixture was stirred at rt overnight before water was added. The layers were separated, and the organic layer was washed with water, dried and concentrated in vacuo to yield 7.4 g (96%) of the title compound.

後処理

  1. additionwas added
  2. customThe layers were separated
  3. washthe organic layer was washed with water
  4. customdried
  5. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-906156b8f442413eb9ef08f7b7eaf71f
出典データセット
uspto-grants-2003_05
特許番号
US06559162B2

関連ノート

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