4-Bromo-3-phenyl-1H-pyrazol-5-amine → 3-[[(4-bromo-5-phenyl-1H-pyrazol-3-yl)amino]methylidene]-1H-indol-2-one

HRID 411674ノート

反応式

HRID 411674 の反応式
NC1C=CNN=1.O/[CH:8]=[C:9]1\[C:10](=[O:18])[NH:11][C:12]2[C:17]\1=[CH:16][CH:15]=[CH:14][CH:13]=2.[Br:19][C:20]1[C:21]([NH2:31])=[N:22][NH:23][C:24]=1[C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1>O1CCCC1>[Br:19][C:20]1[C:21]([NH:31][CH:8]=[C:9]2[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[NH:11][C:10]2=[O:18])=[N:22][NH:23][C:24]=1[C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1

参加物

5

反応物 3

HCID 5943194-Bromo-3-phenyl-1H-pyrazol-5-amineHCID 178418806HCID 178418806、化合物HCID 178517101HCID 178517101、化合物

生成物 1

HCID 1785171003-[[(4-bromo-5-phenyl-1H-pyrazol-3-yl)amino]methylidene]-1H-indol-2-one

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

The named compound is prepared by substituting 4-bromo-5-phenyl-1H-pyrazol-3-ylamine for 3-aminopyrazole in the reaction of Example 1. Specifically, E & Z-3-[(hydroxy)-methylene]-1,3-dihydro-indol-2-one (0.1489 gms.) is reacted with 0.4557 gms. of 4-bromo-5-phenyl-1H-pyrazol-3-ylamine by refluxing in tetrahydrofuran (3.0 mL).

後処理

  1. customThe named compound is prepared
  2. customin the reaction of Example 1

出典と根拠

ORDレコード
ord-3456c435d9fd486fa12b5069e1657e9b
出典データセット
uspto-grants-2003_05
特許番号
US06559173B1

反応ノート

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