Sodium Iodide → N-[3-(iodoacetyl)-2-oxo-1-imidazolidinyl]carbamic acid, 1,1-dimethylethyl ester

HRID 4119ノート

反応式

HRID 4119 の反応式
Br[CH2:2][C:3]([N:5]1[CH2:9][CH2:8][N:7]([NH:10][C:11](=[O:17])[O:12][C:13]([CH3:16])([CH3:15])[CH3:14])[C:6]1=[O:18])=[O:4].[I-:19].[Na+]>CC(C)=O>[I:19][CH2:2][C:3]([N:5]1[CH2:9][CH2:8][N:7]([NH:10][C:11](=[O:17])[O:12][C:13]([CH3:16])([CH3:15])[CH3:14])[C:6]1=[O:18])=[O:4]

参加物

4

反応物 2

HCID 5238Sodium IodideHCID 57105682N-[3-(Bromoacetyl)-2-oxo-1-imidazolidinyl]carbamic acid, 1,1-dimethylethyl ester

生成物 1

HCID 57241819N-[3-(iodoacetyl)-2-oxo-1-imidazolidinyl]carbamic acid, 1,1-dimethylethyl ester

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

N-[3-(Bromoacetyl)-2-oxo-1-imidazolidinyl]carbamic acid, 1,1-dimethylethyl ester (20.9 g, 65 mmol) was dissolved in acetone (250 ml) containing sodium iodide (10.5 g, 70 mmol). The solution was stirred at reflux for three hours and filtered hot through Celite. The solution was evaporated in vacuo to give the title compound as a light yellow solid, 23.9 g.

後処理

  1. temperatureat reflux for three hours
  2. filtrationfiltered hot through Celite
  3. customThe solution was evaporated in vacuo

出典と根拠

ORDレコード
ord-71dd9c746bed41b09c643f7528bb9407
出典データセット
uspto-grants-1988_02
特許番号
US04723002

反応ノート

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