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4,5-Dichloro-2-fluoroaniline → 4-[(3,4-Dichloro-6-fluorophenyl)amino]-6-nitroquinazoline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4,5-Dichloro-2-fluoroaniline | HCID 223091 | — |
| 反応物 | 4-Chloro-6-nitroquinazoline | HCID 11356257 | — |
| 溶媒 | Isopropanol | HCID 3776 | — |
| 生成物 | 4-[(3,4-Dichloro-6-fluorophenyl)amino]-6-nitroquinazoline | HCID 15480998 | — |
反応手順
3,4-Dichloro-6-fluoroaniline (1 equivalent) was reacted with 4-chloro-6-nitroquinazoline (3.5 equivalents), in iso-propylalcohol. After filtration, 4-[(3,4-dichloro-6-fluorophenyl)amino]-6-nitroquinazoline (compound 1) was obtained in 78% yield.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06562319B2 |
| 出典データセット | uspto-grants-2003_05 |
| ORD ID | ord-4a4f25d577154b809f69c5e6408ff8e5 |
| 出典メモ | uspto-grants-2003_05 |