huagongshe.com
HRID411947

反应详情

EQUATION

反应方程式

HRID 411947 的结构方程式

REACTANTS

反应物

2
结构：Nc1cc(Cl)c(Cl)cc1F
HCID223091

4,5-dichloro-2-fluoroaniline

C6H4Cl2FN

结构：O=[N+]([O-])c1ccc2ncnc(Cl)c2c1
HCID11356257

4-Chloro-6-nitroquinazoline

C8H4ClN3O2

PRODUCTS

生成物

1
结构：O=[N+]([O-])c1ccc2ncnc(Nc3cc(Cl)c(Cl)cc3F)c2c1
HCID15480998

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CC(C)O
溶剂HCID3776

Isopropanol

C3H8O

PROCEDURE

实验过程

3,4-Dichloro-6-fluoroaniline (1 equivalent) was reacted with 4-chloro-6-nitroquinazoline (3.5 equivalents), in iso-propylalcohol. After filtration, 4-[(3,4-dichloro-6-fluorophenyl)amino]-6-nitroquinazoline (compound 1) was obtained in 78% yield.

WORKUP

后处理

  1. filtrationAfter filtration