関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Benzyl Bromide | HCID 7498 | — |
| 反応物 | Ethyl Acetate | HCID 8857 | — |
| 反応物 | Lithium Carbonate | HCID 11125 | — |
| 反応物 | 2,5-Dihydroxybenzaldehyde | HCID 70949 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 2-(Benzyloxy)-5-hydroxybenzaldehyde | HCID 18536192 | — |
反応手順
To a solution of 2,5-dihydroxybenzaldehyde (10.41 g, 75.4 mmol) in 100 mL of DMF was added lithium carbonate (16.71 g, 226 mmol), followed by benzyl bromide (13.5 mL, 113 mmol). The solution was warmed to 60° C. and stirred for 30 hours. The reaction was poured into EtOAc and washed with water, saturated NaHCO3 solution and brine, dried (Na2SO4), filtered, and concentrated in vacuo. The product was isolated as a brown oil which was used without further purification.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06562823B1 |
|---|
| 出典データセット | uspto-grants-2003_05 |
|---|
| ORD ID | ord-3644a0c03a8047b489215c373b988329 |
|---|
| 出典メモ | uspto-grants-2003_05 |
|---|
