反应详情

温度

60 °C

To a solution of 2,5-dihydroxybenzaldehyde (10.41 g, 75.4 mmol) in 100 mL of DMF was added lithium carbonate (16.71 g, 226 mmol), followed by benzyl bromide (13.5 mL, 113 mmol). The solution was warmed to 60° C. and stirred for 30 hours. The reaction was poured into EtOAc and washed with water, saturated NaHCO3 solution and brine, dried (Na2SO4), filtered, and concentrated in vacuo. The product was isolated as a brown oil which was used without further purification.

1. washwashed with water, saturated NaHCO3 solution and brine
2. dry with materialdried (Na2SO4)
3. filtrationfiltered
4. concentrationconcentrated in vacuo
5. customThe product was isolated as a brown oil which
6. customwas used without further purification