3-Chlorobenzaldehyde → 2-m-Chlorophenyl-3-(3-trifluoromethyl-4-fluorophenyl)-5-ethyl oxazolidine

HRID 4122

反応式

HRID 4122 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][CH:9]=1)[CH:5]=[O:6].[F:10][C:11]([F:26])([F:25])[C:12]1[CH:13]=[C:14]([NH:19][CH2:20][CH:21](O)[CH2:22][CH3:23])[CH:15]=[CH:16][C:17]=1[F:18]>CS(O)(=O)=O>[Cl:1][C:2]1[CH:3]=[C:4]([CH:5]2[N:19]([C:14]3[CH:15]=[CH:16][C:17]([F:18])=[C:12]([C:11]([F:26])([F:10])[F:25])[CH:13]=3)[CH2:20][CH:21]([CH2:22][CH3:23])[O:6]2)[CH:7]=[CH:8][CH:9]=1

参加物

4

反応物 2

HCID 114773-ChlorobenzaldehydeHCID 201526711-(3-Trifluoromethyl-4-fluorophenylamino)-2-butanol

生成物 1

HCID 201526702-m-Chlorophenyl-3-(3-trifluoromethyl-4-fluorophenyl)-5-ethyl oxazolidine

試薬・触媒・溶媒 1

HCID 6395Methanesulfonic Acid触媒

実験手順

Meta-chlorobenzaldehyde (2.3 g, 0.016 mole) was combined with 5 g of 1-(3-trifluoromethyl-4-fluorophenylamino)-2-butanol and 3 drops of methane sulfonic acid was added. The mixture was heated on the steam bath for about one hour and stripped on the rotary evaporator. The product, a sticky, thick liquid, was characterized by IR and NMR.

後処理

  1. additionwas added
  2. temperatureThe mixture was heated on the steam bath for about one hour
  3. customstripped on the rotary evaporator

出典と根拠

ORDレコード
ord-2606b9cbf440416d8f3e63a1500dbed7
出典データセット
uspto-grants-1988_02
特許番号
US04723986

関連ノート

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