Ninhydrin → 5-(S)-Acetamidomethyl-3-[4'-dimethoxymethyl-3'-fluorophenyl]-oxazolidine-2-one

HRID 412490ノート

反応式

HRID 412490 の反応式
[C:1](OC(=O)C)(=[O:3])[CH3:2].N1C=CC=CC=1.ClCCl.[NH2:17][CH2:18][C@@H:19]1[O:23][C:22](=[O:24])[N:21]([C:25]2[CH:30]=[CH:29][C:28]([CH:31]([O:34][CH3:35])[O:32][CH3:33])=[C:27]([F:36])[CH:26]=2)[CH2:20]1.C1C=C2C(C(O)(O)C(=O)C2=CC=1)=O>>[C:1]([NH:17][CH2:18][C@@H:19]1[O:23][C:22](=[O:24])[N:21]([C:25]2[CH:30]=[CH:29][C:28]([CH:31]([O:32][CH3:33])[O:34][CH3:35])=[C:27]([F:36])[CH:26]=2)[CH2:20]1)(=[O:3])[CH3:2]

参加物

4

反応物 3

HCID 10236NinhydrinHCID 20443498acetic anhydride pyridine CH2Cl2HCID 229773175-(S)-Aminomethyl-3-[4'-dimethoxymethyl-3'-fluorophenyl]-oxazolidine-2-one

生成物 1

HCID 229773135-(S)-Acetamidomethyl-3-[4'-dimethoxymethyl-3'-fluorophenyl]-oxazolidine-2-one

実験手順

Acetic anhydride-pyridine-dichloromethane solution (1 to 1.5 to 3, 4 mL) was added to BAL resin immobilized 5-(S)-aminomethyl-3-[4′-dimethoxymethyl-3′-fluorophenyl]-oxazolidine-2-one, and the mixture was agitated for ca. 2 h (until negative ninhydrine test indicated completion of the acylation). The resin was filtered, washed liberally with methanol and dichloromethane and dried under vacuum.

後処理

  1. filtrationThe resin was filtered
  2. washwashed liberally with methanol and dichloromethane
  3. customdried under vacuum

出典と根拠

ORDレコード
ord-939e58bc94b943b5b8899cb6c62f791f
出典データセット
uspto-grants-2003_05
特許番号
US06562844B2

反応ノート

読み込み中…