Hydrochloric Acid → 4-(2-Amidino-1,2,3,4-tetrahydroisoquinolin-7-yloxymethyl)-1-(pyridin-4-yl)piperidine-4-carboxylic acid hydrochloride

HRID 412528ノート

反応式

HRID 412528 の反応式
[C:1]([N:4]1[CH2:13][CH2:12][C:11]2[C:6](=[CH:7][C:8]([O:14][CH2:15][C:16]3([C:28]([OH:30])=[O:29])[CH2:21][CH2:20][N:19]([C:22]4[CH:27]=[CH:26][N:25]=[CH:24][CH:23]=4)[CH2:18][CH2:17]3)=[CH:9][CH:10]=2)[CH2:5]1)(=[NH:3])[NH2:2].[ClH:31].[OH-].[Na+]>O>[ClH:31].[C:1]([N:4]1[CH2:13][CH2:12][C:11]2[C:6](=[CH:7][C:8]([O:14][CH2:15][C:16]3([C:28]([OH:30])=[O:29])[CH2:17][CH2:18][N:19]([C:22]4[CH:23]=[CH:24][N:25]=[CH:26][CH:27]=4)[CH2:20][CH2:21]3)=[CH:9][CH:10]=2)[CH2:5]1)(=[NH:2])[NH2:3]

参加物

5

反応物 3

HCID 313Hydrochloric Acid2 回HCID 14798Sodium HydroxideHCID 9844392JTV-803 free base

生成物 1

HCID 696972654-(2-Amidino-1,2,3,4-tetrahydroisoquinolin-7-yloxymethyl)-1-(pyridin-4-yl)piperidine-4-carboxylic acid hydrochloride

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
60 °C

実験手順

4-(2-Amidino-1,2,3,4-tetrahydroisoquinolin-7-yloxymethyl)-1-(pyridin-4-yl)piperidine-4-carboxylic acid (7.55 g) was suspended in water (135 ml) and 1N hydrochloric acid (20 ml) was added. The mixture was heated to 60° C. and thereto was successively added dropwise 1N aqueous sodium hydroxide solution (2.9 ml) and 1N hydrochloric acid (1 ml). The mixture was stood at room temperature for 12 hours and the resultant crystals were collected by filtration, washed with water and dried to give the title compound (4.7 g).

後処理

  1. filtrationthe resultant crystals were collected by filtration
  2. washwashed with water
  3. customdried

出典と根拠

ORDレコード
ord-733bf2d663034007ad71985e84407451
出典データセット
uspto-grants-2003_05
特許番号
US06562828B1

反応ノート

読み込み中…