Hydrogen Bromide → 1,2,3,4-Tetrahydroisoquinolin-6-ol hydrobromide

反応式

C[O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[CH2:9][NH:8][CH2:7][CH2:6]2.[BrH:13]>>[BrH:13].[OH:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[CH2:9][NH:8][CH2:7][CH2:6]2

参加物

反応物 2

HCID 260Hydrogen Bromide

HCID 393566-Methoxy-1,2,3,4-tetrahydroisoquinoline

生成物 1

HCID 133617991,2,3,4-Tetrahydroisoquinolin-6-ol hydrobromide

実験手順

6-Methoxy-1,2,3,4-tetrahydroisoquinoline (2.89 g) was dissolved in 48% aqueous hydrogen bromide solution (70 ml) and the mixture was refluxed for 2 hours. The solvent was evaporated and to the obtained residue were added ethanol and diethyl ether. The mixture was filtrated and dried under reduced pressure to give the title compound (3.93 g).

後処理

temperaturethe mixture was refluxed for 2 hours
customThe solvent was evaporated and to the obtained residue
additionwere added ethanol and diethyl ether
filtrationThe mixture was filtrated
customdried under reduced pressure

出典と根拠

ORDレコード: ord-45378efb71f6493387a5248cd1d3c7af
出典データセット: uspto-grants-2003_05
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06562828B1

反応ノート

読み込み中…

参加物