Hydrogen Bromide → 2,3,4,5-tetrahydro-1H-2-benzazepin-8-ol hydrobromide

HRID 412595ノート

反応式

HRID 412595 の反応式
C[O:2][C:3]1[CH:4]=[CH:5][C:6]2[CH2:12][CH2:11][CH2:10][NH:9][CH2:8][C:7]=2[CH:13]=1.[BrH:14]>>[BrH:14].[OH:2][C:3]1[CH:4]=[CH:5][C:6]2[CH2:12][CH2:11][CH2:10][NH:9][CH2:8][C:7]=2[CH:13]=1

参加物

3

反応物 2

HCID 260Hydrogen BromideHCID 154969548-Methoxy-2,3,4,5-tetrahydro-1H-benzo(c)azepine

生成物 1

HCID 114479102,3,4,5-tetrahydro-1H-2-benzazepin-8-ol hydrobromide

実験手順

8-Methoxy-2,3,4,5-tetrahydro-1H-benz[c]azepine (3.65 g) was dissolved in 48% aqueous hydrogen bromide solution (36 ml) and the mixture was refluxed for 2 hours. The solvent was evaporated and ethanol and diethyl ether were added to the obtained residue. The mixture was filtrated and dried under reduced pressure to give the title compound (4.56 g).

後処理

  1. temperaturethe mixture was refluxed for 2 hours
  2. customThe solvent was evaporated
  3. additionethanol and diethyl ether were added to the obtained residue
  4. filtrationThe mixture was filtrated
  5. customdried under reduced pressure

出典と根拠

ORDレコード
ord-949b71e773254f5188db2f623d3f8843
出典データセット
uspto-grants-2003_05
特許番号
US06562828B1

反応ノート

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